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Quiroga, J.; Portilla, J.; Abonía, R.; Insuasty, B.; Nogueras, M.; Cobo, J. Synthesis of Novel 5-Amino-1-Aroylpyrazoles. Tetrahedron Lett. 2008, 49 (41), 5943–5945. https://doi.org/10.1016/j.tetlet.2008.07.166. ![](/images/Tetrahedron_2008_Aroil_B.png)
Quiroga, J.; Portilla, J.; Abonía, R.; Insuasty, B.; Nogueras, M.; Cobo, J. Regioselective Synthesis of Novel Substituted Pyrazolo[1,5-a]Pyrimidines under Solvent-Free Conditions. Tetrahedron Lett. 2008, 49 (43), 6254–6256. https://doi.org/10.1016/j.tetlet.2008.08.044.![](/images/2008c.png)
Quiroga, J.; Portilla, J.; Cruz, S.; Abonía, R.; Insuasty, B. Solvent-Free Synthesis of Fused Pyrazolo[1,5-a]Pyrimidines by Reaction of 5-Amino-1H-Pyrazoles and β-Triketones. Open Org. Chem. J. 2008, 2, 92–99. https://doi.org/10.2174/1874095200801020092.![](/images/2008d.png)
Quiroga, J.; Portilla, J.; Cobo, J.; Glidewell, C. A Simple Hydrogen-Bonded Chain in (3Z)-3-{1-[(5-Phenyl-1H-Pyrazol-3-Yl) Amino]Ethyl-Idene}-4,5-Dihydro-Furan-2(3H)-One, and a Hydrogen-Bonded Ribbon of Centrosymmetric Rings in the Self-Assembled Adduct (3Z)-3-{1-[(5-Methyl-1H- Pyrazol-3-Yl)Amino]Ethyl-Id. Acta Crystallogr. Sect. C Cryst. Struct. Commun. 2010, 66 (1), 25–28. https://doi.org/10.1107/S0108270109052846.![](/images/ActaC_2010a.png)
Portilla, J.; Estupiñan, D.; Cobo, J.; Glidewell, C. 7-Amino-5-Methyl-2-Phenyl-6-(Phenyl-Diazenyl)Pyrazolo[1,5-a]Pyrimidine Crystallizes with Z′ = 2: Pseudosymmetry and the Formation of Complex Sheets Built from N-H⋯N and C-H⋯π(Arene) Hydrogen Bonds. Acta Crystallogr. Sect. C Cryst. Struct. Commun. 2010, 66 (3), 133–136. https://doi.org/10.1107/S0108270110003549.![](/images/ActaC_2010b.png)
Quiroga, J.; Portilla, J.; Hursthouse, M. B.; Cobo, J.; Glidewell, C. 5-Amino-1-Benzoyl-3-Methyl-Pyrazole: Complex Sheets Built from N-H⋯N, C-H⋯d C-H(Are⋯πne) Hydrogen Bonds. Acta Crystallogr. Sect. C Cryst. Struct. Commun. 2010, 66 (4), 159–162. https://doi.org/10.1107/S0108270110006980.![](/images/ActaC_2010c.png)
Portilla, J.; Lizarazo, C.; Cobo, J.; Glidewell, C. A π-Stacked Chain of Hydrogen-Bonded Dimers in 3-Tert-Butyl-1-(4-Chloro- Phen-Yl)-4-Phenyl-Indeno-[1,2-b]Pyrazolo-[4,3-e]Pyridin-5(1H)-One and a π-Stacked Sheet of Hydrogen-Bonded Chains in 3-Tert-Butyl-1-(4-Chloro-Phen- Yl)-4-(4-Meth-Oxy-Phen-Yl)Indeno-[. Acta Crystallogr. Sect. C Cryst. Struct. Commun. 2011, 67 (12), 749–483. https://doi.org/10.1107/S0108270111045082.![](/images/RSC_JOH_2019.png)
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Portilla, J.; Ontiveros, I.; Cobo, J.; Glidewell, C. 5-5-Methyl-N-[2-Nitro-4-(Trifluoromethyl) Phenyl]-1H-Pyrazole-3-Amine: A Chain of Hydrogen-Bonded R22 (6) and R22 (16) Rings. Acta Crystallogr. Sect. C Cryst. Struct. Commun. 2013, 69 (2), 172–174. https://doi.org/10.1107/S0108270113000607.
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Orrego Hernandez, J.; Portilla, J.; Cobo, J.; Glidewell, C. Two Different Products from the Reaction of 1-Aryl-5-Chloro-3-Methyl-1H-Pyrazole-4-Carbaldehyde with Cyclohexylamine When the Aryl Substituent Is Phenyl or Pyridin-2-Yl: Hydrogen-Bonded Sheets versus Dimers. Acta Crystallogr. Sect. C Struct. Chem. 2015, 71, 363–368. https://doi.org/10.1107/S2053229615006403.![](/images/2015a.png)
Orrego-Hernández, J.; Cobo, J.; Portilla, J. Chemoselective Synthesis of 5-Alkylamino-1H-Pyrazole-4-Carbaldehydes by Cesium- and Copper-Mediated Amination. Eur. J. Org. Chem. 2015, 2015 (23), 5064–5069. https://doi.org/10.1002/ejoc.201500505.![](/images/2015b.png)