Castillo, J.-C.; Portilla, J.; Insuasty, B.; Quiroga, J.; Abonia, R. A Straightforward Synthesis of 4,7-Disubstituted 1,4-Oxazepanes via a Br∅nsted Acid-Catalyzed Intramolecular Etherification Reaction. Curr. Org. Synth. 2018, 15, 370–379. https://doi.org/10.2174/1570179414666171011160917.  

Castillo, J. C.; Tigreros, A.; Portilla, J. 3-Formylpyrazolo[1,5-a]Pyrimidines as Key Intermediates for the Preparation of Functional Fluorophores. J. Org. Chem. 2018, 83 (18), 10887–10897. https://doi.org/10.1021/acs.joc.8b01571.

Macías, M. A.; Castillo, J. C.; Portilla, J. A Series of (E)-5-(Arylideneamino)-1-Tert-Butyl-1H-Pyrrole-3-Carbonitriles and Their Reduction Products to Secondary Amines: Syntheses and X-Ray Structural Studies. Acta Crystallogr. Sect. C Struct. Chem. 2018, 74 (1), 82–93. https://doi.org/10.1107/S2053229617017260.  

Castillo, J. C.; Portilla, J. Recent Advances in the Synthesis of New Pyrazole Derivatives. Targets Heterocycl. Syst. 2018, 22, 194–223. https://doi.org/10.17374/targets.2019.22.194.  

Castillo, J. C.; Jiménez, E.; Portilla, J.; Insuasty, B.; Quiroga, J.; Moreno-Fuquen, R.; Kennedy, A. R.; Abonia, R. Application of a Catalyst-Free Domino Mannich/Friedel-Crafts Alkylation Reaction for the Synthesis of Novel Tetrahydroquinolines of Potential Antitumor Activity. Tetrahedron 2018, 74 (9), 932–947. https://doi.org/10.1016/j.tet.2017.12.049.  

Elejalde, N. R.; Macías, M.; Castillo, J. C.; Sortino, M.; Svetaz, L.; Zacchino, S.; Portilla, J. Synthesis and in Vitro Antifungal Evaluation of Novel N-Substituted 4-Aryl-2-Methylimidazoles. ChemistrySelect 2018, 3 (18), 5220–5227. https://doi.org/10.1002/slct.201801238.  

Macías, M. A.; Elejalde, N. R.; Butassi, E.; Zacchino, S.; Portilla, J. Studies via X-Ray Analysis on Intermolecular Interactions and Energy Frameworks Based on the Effects of Substituents of Three 4-Aryl-2-Methyl-1H-Imidazoles of Different Electronic Nature and Their in Vitro Antifungal Evaluation. Acta Crystallogr. Sect. C Struct. Chem. 2018, 74 (11), 1447–1458. https://doi.org/10.1107/S2053229618014109. 

Tigreros, A.; Rosero, H. A.; Castillo, J. C.; Portilla, J. Integrated Pyrazolo[1,5-a]Pyrimidine–Hemicyanine System as a Colorimetric and Fluorometric Chemosensor for Cyanide Recognition in Water. Talanta 2019, 196, 395–401. https://doi.org/10.1016/j.talanta.2018.12.100.  

Castillo, J. C.; Tigreros, A.; Coquerel, Y.; Rodríguez, J.; Macías, M. A.; Portilla, J. Synthesis of Pyrrolo[2,3-c]Isoquinolines via the Cycloaddition of Benzyne with Arylideneaminopyrroles: Photophysical and Crystallographic Study. ACS Omega 2019, 4 (17), 17326–17339. https://doi.org/10.1021/acsomega.9b02043.  

García, M.; Romero, I.; Portilla, J. Synthesis of Fluorescent 1,7-Dipyridyl-Bis-Pyrazolo[3,4-b:4′,3′-e]Pyridines: Design of Reversible Chemosensors for Nanomolar Detection of Cu2+. ACS Omega 2019, 4 (4), 6757–6768. https://doi.org/10.1021/acsomega.9b00226.  

Orrego-Hernández, J.; Cobo, J.; Portilla, J. Synthesis, Photophysical Properties, and Metal-Ion Recognition Studies of Fluoroionophores Based on 1-(2-Pyridyl)-4-Styrylpyrazoles. ACS Omega 2019, 4 (15), 16689–16700. https://doi.org/10.1021/acsomega.9b02796. 

Orrego-Hernández, J.; Lizarazo, C.; Cobo, J.; Portilla, J. Pyrazolo-Fused 4-Azafluorenones as Key Reagents for the Synthesis of Fluorescent Dicyanovinylidene-Substituted Derivatives. RSC Adv. 2019, 9 (47), 27318–27323. https://doi.org/10.1039/c9ra04682h.

Garzón, L. M.; Portilla, J. Synthesis of Novel D–π–A Dyes for Colorimetric Cyanide Sensing Based on Hemicyanine–Functionalized N-(2-Pyridyl)Pyrazoles. Eur. J. Org. Chem. 2019, 2019 (42), 7079–7088. https://doi.org/10.1002/ejoc.201901178.  

Elejalde, N. R.; Butassi, E.; Zacchino, S.; Macías, M. A.; Portilla, J. Inter­molecular Inter­action Energies and Molecular Conformations in N-Substituted 4-Aryl-2-Methyl­imidazoles with Promising in Vitro Anti­fungal Activity. Acta Crystallogr. Sect. B Struct. Sci. Cryst. Eng. Mater. 2019, 75, 1197–1207. https://doi.org/10.1107/S2052520619013271.