Tigreros, A.; Aranzazu, S.-L.; Bravo, N.-F.; Zapata-Rivera, J.; Portilla, J. Pyrazolo[1,5-a]Pyrimidines Based Fluorophores: A Comprehensive Theoretical-Experimental Study. RSC Adv. 2020, 10, 39542–39552. https://doi.org/https://doi.org/10.1039/D0RA07716J. 

Tigreros, A.; Portilla, J. Recent Progress in Chemosensors Based on Pyrazole Derivatives. RSC Adv. 2020, 10 (33), 19693–19712. https://doi.org/10.1039/d0ra02394a. 

Tigreros, A.; Castillo, J. C.; Portilla, J. Cyanide Chemosensors Based on 3-Dicyanovinylpyrazolo[1,5-a]Pyrimidines: Effects of Peripheral 4-Anisyl Group Substitution on the Photophysical Properties. Talanta 2020, 215, 120905. https://doi.org/10.1016/j.talanta.2020.120905. 

Martínez, J. J.; Páez, L. A.; Gutiérrez, L. F.; Pardo Cuervo, O. H.; Rojas, H. A.; Romanelli, G. P.; Portilla, J.; Castillo, J.-C.; Becerra, D. Obtaining Protoanemonin through Selective Oxidation of D-Fructose and 5-(Hydroxymethyl)Furfural in a Self-Catalysed Reaction. Asian J. Org. Chem. 2020, 9 (12), 2184–2190. https://doi.org/10.1002/ajoc.202000406. 

Vargas-Oviedo, D.; Butassi, E.; Zacchino, S.; Portilla, J. Eco-Friendly Synthesis and Antifungal Evaluation of N-Substituted Benzimidazoles. Monatshefte fur Chemie 2020, 151 (4), 575–588. https://doi.org/10.1007/s00706-020-02575-9. 

Chaparro, S.; Rojas, H.; Castillo, J.; Portilla, J.; Romanelli, G.; Pineda, A.; Elsharif, A.; Martinez, J. J.; Luque, R. Solventless Amide Synthesis Catalyzed by Biogenic CaCO3 Materials. ACS Sustain. Chem. Eng. 2020, 8 (35), 13139–13146. https://doi.org/10.1021/acssuschemeng.0c04429. 

Castillo, J. C.; Bravo, N. F.; Tamayo, L. V.; Mestizo, P. D.; Hurtado, J.; Macías, M.; Portilla, J. Water-Compatible Synthesis of 1,2,3-Triazoles under Ultrasonic Conditions by a Cu(I) Complex-Mediated Click Reaction. ACS Omega 2020, 5 (46), 30148–30159. https://doi.org/10.1021/acsomega.0c04592.

Tigreros, A.; Zapata-Rivera, J.; Portilla, J. Pyrazolo[1,5-a]Pyrimidinium Salts for Cyanide Sensing: A Performance and Sustainability Study of the Probes. ACS Sustain. Chem. Eng. 2021, 9, 12058–12069. https://doi.org/10.1021/acssuschemeng.1c01689.  

Tigreros, A.; Macías, M.; Portilla, J. Photophysical and Crystallographic Study of Three Integrated Pyrazolo[1,5-a]Pyrimidine–Triphenylamine Systems. Dye. Pigment. 2021, 184, 108730. https://doi.org/10.1016/j.dyepig.2020.108730.  

Tigreros, A.; Portilla, J. Fluorescent Pyrazole Derivatives: An Attractive Scaffold for Biological Imaging Applications. Curr. Chinese Sci. 2021, 1 (2), 197–206. https://doi.org/10.2174/2210298101999201208211116.  

Tigreros, A.; Portilla, J. Pyrazolo[1,5-a]Pyrimidines an Interesting Scaffold for Optical Applications. Mod. Approaches Mater. Sci. 2021, 4 (1), 457–458. https://doi.org/10.32474/MAMS.2021.04.000178.  

Gómez, A. A.; Godoy, A.; Portilla, J. Functional Pyrazolo[1,5-a]Pyrimidines: Current Approaches in Synthetic Transformations and Uses as an Antitumor Scaffold. Molecules 2021, 26 (9), 2708. https://doi.org/10.3390/molecules26092708.  

Vargas-Oviedo, D.; Portilla, J.; Macías, M. A. Influence of the Haloaryl Moiety over the Molecular Packing in N-Phenacylbenzimidazoles Crystallizing in the Same Space Group. J. Mol. Struct. 2021, 1230, 129869. https://doi.org/10.1016/j.molstruc.2020.129869.  

Serrano-Sterling, C.; Becerra, D.; Portilla, J.; Rojas, H.; Macías, M.; Castillo, J. C. Synthesis, Biological Evaluation and X-Ray Crystallographic Analysis of Novel (E)-2-Cyano-3-(Het)Arylacrylamides as Potential Anticancer Agents. J. Mol. Struct. 2021, 1244, 130944. https://doi.org/10.1016/j.molstruc.2021.130944.

Rios, M.-C.; Bravo, N.-F.; Sánchez, C.-C.; Portilla, J. Chemosensors Based on N-Heterocyclic Dyes : Advances in Sensing Highly Toxic Ions Such as CN− and Hg2+. RSC Adv. 2021, 11, 34206−34234. https://doi.org/10.1039/D1RA06567J. 

Moreno-Fuquen, R.; Hincapié-Otero, M. M.; Becerra, D.; Castillo, J. C.; Portilla, J.; Macías, M. A. Synthesis of 1-Aroyl-3-Methylsulfanyl-5-Amino-1,2,4-Triazoles and Their Analysis by Spectroscopy, X-Ray Crystallography and Theoretical Calculations. J. Mol. Struct. 2021, 1226, 129317. https://doi.org/10.1016/j.molstruc.2020.129317. 

Ortiz, M.-C.; Portilla, J. Access to Five-Membered N-Heteroaromatic Compounds: Current Approach Based on Microwave-Assisted Synthesis. Targets Heterocycl. Syst. 2021, 25, 436–462. https://doi.org/10.17374/targets.2022.25.436.